L . E . D . S . S .
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alpha-Methylamino-benzo[b][1,7]phenanthroline-methanol:a DNA Intercalating Drug with Alkylating Properties
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LEDSS Université J. Fourier, BP 53, 38041 Grenoble cedex, FRANCE
Introduction
Synthesis
Reactivity studies
1- Heterolytic reactions: Quinone-imine-methide intermediate as a highly
electrophilic species
2- Homolytic reactions: Photochemical degradation
3- Reactivity on DNA: covalent binding of the drug to the macromolecule
General Conclusion
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