Aldol Type Reactions of the Pyrrolidinone
Generation of the silyl enol ether (10) has allowed a
variety of aldol type-reactions to be performed:
Fluoride ion mediated aldol reactions.4
Line broadening occurs in the 1H NMR due to amide resonance, but
high temperature NMR has improved the resolution of the peaks.
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Dehydration of the beta-hydroxy ketones to the enone has been achieved.
Lewis Acid Mediated aldol reactions
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