Email Discussion:
Keynote paper 4 - Stan Roberts et al
METH-COHN Otto
Email Discussion:
Re: Keynote Paper 4:(fao METH-COHN Otto)
Nick Turner
Recent Developments in the Use of Enzyme Catalysed Reactions
in Organic Synthesis Resulting from Work at Exeter University
Department of Chemistry, University
of Exeter, Stocker Road, Exeter, Devon, UK, EX4 4QD
Contents
- Introduction
- Hydrolases
- enzyme-catalysed hydrolyses of carboxylic acid esters and amides, phosphate
esters, nitriles and epoxides;
- esterification and inter-esterification reactions catalysed by enzymes;
- Oxidoreductases
- reduction of ketones to secondary alcohols using whole-cell systems or
isolated dehydrogenases;
- oxidation of alicyclic and aromatic substrates using mono-oxygenases and
di-oxygenases in bacteria and fungi including enzyme-catalysed Baeyer-Villiger
oxidations;
- Carbon-carbon bond forming reactions
- aldol reactions;
- formation of optically active cyanohydrins and enzyme-catalysed acyloin
type reactions.
- Future Developments of Biotransformations
- The use of these biocatalytic methods for the stereocontrolled preparation of
important target structures is reviewed and some of the future directions for
the biotransformation area are discussed.
